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Human genetics > research > tumor genetics > animal models last update: 2008-05-26 tumor genetics        breast cancer    colon cancer    paragangliomas    desmoid tumors    animal models desmoid tumor research desmoid tumors are fibromatous lesions occurring both sporadically and in 10-15% of patients with the familial colorectal cancer syndrome, fap (familial adenomatous polyposis). buying generic viagra While death due to colorectal cancer is effectively prevented by colectomy, surgically induced desmoid disease has now become the leading cause of death among fap patients. Treatment is hampered by the fact that surgical trauma often induces desmoid growth in the bowel mesentery or abdominal wall, and the tumors respond poorly to other kind of treatments. There is a great need therefore to be able to predict which fap patient has a high risk to develop desmoid disease, as well as for new drug-based intervention strategies. buy viagra without prescription The present research program in this unit is: characterization of somatic genetic events in human desmoids tumors search for genetic factors that may modify the risk to develop desmoid tumors in apc gene carriers elucidation of the molecular and cellular mechanisms underlying desmoid disease in a mouse model   els robanus maandag (9511). 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Alger has medaled for the fourth year in a row at the San Francisco Chronicle Wine Competition.

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